The Parekh Lab
Research led by Dr. Kal Parekh focuses on airway stem cell depletion as a mechanism for pulmonary allograft failure. The lab has developed a clinically relevant animal model of lung transplantation in the ferret. Orthotopically transplanted ferret lung allografts develop the full spectrum of inflammatory and fibrotic pathology that is seen in human allografts. Our lab leverages this model to investigate how impaired epithelial regeneration leads to fibrosis and to discover the mechanisms that lead to the depletion of endogenous airway stem cells in transplanted lungs. We use quantitative approaches to study airway stem cells throughout the lung and investigate mechanisms that impact their multipotency and self-renewal in health and disease.
Pictured: Immunofluorescent image of an airway with obliterative bronchiolitis. The stylized image shows keratin 8 staining in cyan, Ki67 staining in red, S100A12 staining in green, and nuclei are shown in grey.
Kal R. Parekh, MBBS, FACS
Nicholas P. Rossi Professor in Cardiothoracic Surgery
Chair, Department of Cardiothoracic Surgery
Professor of Anatomy and Cell Biology
Physician-scientist Kal R. Parekh studies lung transplantation and the role of epithelial stem cells in preventing the development of progressively fatal chronic lung allograft dysfunction.
Life in the Parekh lab:
Scientific discourse is enriched when individuals with varied and multifaceted perspectives are included and heard, and cultivating a productive, curious, and creative lab culture is a team effort.
GME Research Resident Physician 4